The relationship between neuron-specific enolase, high sensitivity C reactive protein, and diabetic peripheral neuropathy in Chinese patients with type 2 diabetes: A prospective nested case–control analysis

Abstract Background Diabetic peripheral neuropathy (DPN) involves a very complex pathogenesis, and there is no neuro-specific marker for risk prediction. Neuron-specific enolase (NSE), key enzyme in glycolysis, has broad spectrum neurotrophic neuroprotective effect on neurons, also cause injury inflammatory response of nerves. The relationship between neuron-specific enolase, highly sensitive c-reactive protein (hsCRP), diabetic remains unclear. We aimed to investigate whether elevated serum NSE hsCRP levels increased the DPN patients with type 2 diabetes. Materials methods In this prospective nested case–control study, total 1072 eligible subjects diabetes constituted follow-up cohort. Demographic data parameters including were collected at baseline. Two screening scales (MNSI MDNS) used assess during period. Nerve conduction studies performed end follow-up. Conditional logistic regression was inspect factors incidence DPN. Results During an average period 5.1 years, 176 developed Serum baseline significantly higher group than matched non-DPN groups ( p < 0.001). positively correlated age amplitude sensory nerve action potential compound muscle lower extremity nerves decreased high tertile NSE. After adjustment matching confusing factor, conditional showed level still 3.176 times that low Conclusion Elevated predicted Chinese which may be associated neuroinflammatory caused by levels, but further are needed.